|Other Names||Probable tubulin polyglutamylase TTLL1, 6---, Tubulin polyglutamylase complex subunit 3, PGs3, Tubulin--tyrosine ligase-like protein 1, TTLL1, C22orf7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Expressed in a wide range of tissues. Has a stronger expression in heart, brain and testis|
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Provided below are standard protocols that you may find useful for product applications.
TTLL1 (Tubulin-tyrosine ligase-like protein 1) is a probable catalytic subunit of the neuronal tubulin polyglutamylase complex.
Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)Janke, C., et al. Science 308(5729):1758-1762(2005)Collins, J.E., et al. Genome Res. 13(1):27-36(2003)Trichet, V., et al. Gene 257(1):109-117(2000)
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