|Other Names||Coiled-coil domain-containing protein 28B, CCDC28B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=It localizes near centrosomes and basal bodies|
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The product of this gene localizes to centrosomes and basal bodies. It interacts and colocalizes with several proteins associated with Bardet-Biedl syndrome.
Bin, J., et al. Hum. Mutat. 30 (7), E737-E746 (2009) Badano, J.L., et al. Nature 439(7074):326-330(2006)
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