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BSND Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8WZ55
Additional Information
Gene ID 7809
Other Names Barttin, BSND, BART
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BSND
Synonyms BART
Function Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral (By similarity).
Tissue Location Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear
Research Areas
Citations (0)
citation

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Background

BSND encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear.

References

Riazuddin, S., et al. Am. J. Hum. Genet. 85(2):273-280(2009)Brochard, K., et al. Nephrol. Dial. Transplant. 24(5):1455-1464(2009)Bircan, Z., et al. Pediatr. Nephrol. 24(4):841-844(2009)Kathiresan, S., et al. Nat. Genet. 41(3):334-341(2009)Kathiresan, S., et al. Nat. Genet. 41(1):56-65(2009)

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$ 277.78
Cat# BP9858b
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