|Other Names||Barttin, BSND, BART|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral (By similarity).|
|Tissue Location||Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear.|
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Provided below are standard protocols that you may find useful for product applications.
BSND encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear.
Riazuddin, S., et al. Am. J. Hum. Genet. 85(2):273-280(2009)Brochard, K., et al. Nephrol. Dial. Transplant. 24(5):1455-1464(2009)Bircan, Z., et al. Pediatr. Nephrol. 24(4):841-844(2009)Kathiresan, S., et al. Nat. Genet. 41(3):334-341(2009)Kathiresan, S., et al. Nat. Genet. 41(1):56-65(2009)
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