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TYROBP Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43914
Peptide ID 90625255
Additional Information
Gene ID 7305
Other Names TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KAR-associated protein, TYROBP, DAP12, KARAP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DAP12, KARAP
Function Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.
Research Areas
Citations (0)

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TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL.


Chen, X., et al. Blood 113(14):3226-3234(2009)Sulonen, A.M., et al. J. Neuroimmunol. 206 (1-2), 86-90 (2009) Lanier, L.L. Immunol. Rev. 227(1):150-160(2009)Schleinitz, N., et al. PLoS ONE 4 (7), E6264 (2009)

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$ 80.00
Cat# BP9862b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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