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CARD8 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y2G2
Peptide ID 90713025
Additional Information
Gene ID 22900
Other Names Caspase recruitment domain-containing protein 8, Apoptotic protein NDPP1, CARD-inhibitor of NF-kappa-B-activating ligand, CARDINAL, DACAR, Tumor up-regulated CARD-containing antagonist of CASP9, TUCAN, CARD8, KIAA0955, NDPP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CARD8
Synonyms KIAA0955, NDPP1
Function Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Cellular Location Cytoplasm. Nucleus
Tissue Location High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow
Research Areas
Citations (0)

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CARD8 encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis.


Hassan, M., et al. Cell. Oncol. 31(6):437-456(2009)Mockelmann, N., et al. BMC Gastroenterol 9, 79 (2009) Checinska, A., et al. BMC Cancer 6, 166 (2006) Agostini, L., et al. Immunity 20(3):319-325(2004)Stilo, R., et al. FEBS Lett. 521 (1-3), 165-169 (2002)

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$ 80.00
Cat# BP9863a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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