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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6PJP8 |
|---|---|
| Peptide ID | 35827 |
| Gene ID | 9937 |
|---|---|
| Other Names | DNA cross-link repair 1A protein, SNM1 homolog A, hSNM1, hSNM1A, DCLRE1A, KIAA0086, SNM1, SNM1A |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DCLRE1A |
|---|---|
| Synonyms | KIAA0086, SNM1, SNM1A |
| Function | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. |
| Cellular Location | Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross- linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1 |
| Tissue Location | Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links.
References
Akhter, S., et al. Biochem. Biophys. Res. Commun. 377(1):236-241(2008)Hemphill, A.W., et al. Mol. Genet. Metab. 94(1):38-45(2008)Hazrati, A., et al. DNA Repair (Amst.) 7(2):230-238(2008)Hejna, J., et al. Nucleic Acids Res. 35(18):6115-6123(2007)
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