|Other Names||DNA cross-link repair 1A protein, SNM1 homolog A, hSNM1, hSNM1A, DCLRE1A, KIAA0086, SNM1, SNM1A|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0086, SNM1, SNM1A|
|Function||May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.|
|Cellular Location||Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross- linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1|
|Tissue Location||Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links.
Akhter, S., et al. Biochem. Biophys. Res. Commun. 377(1):236-241(2008)Hemphill, A.W., et al. Mol. Genet. Metab. 94(1):38-45(2008)Hazrati, A., et al. DNA Repair (Amst.) 7(2):230-238(2008)Hejna, J., et al. Nucleic Acids Res. 35(18):6115-6123(2007)
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