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APPL1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UKG1
Peptide ID 90723013
Additional Information
Gene ID 26060
Other Names DCC-interacting protein 13-alpha, Dip13-alpha, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1, APPL1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name APPL1
Function Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Cellular Location Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear Translocated into the nucleus upon release from endosomal membranes following internalization of EGF
Tissue Location High levels in heart, ovary, pancreas and skeletal muscle.
Research Areas
Citations (0)

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APPL1 encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.


Banach-Orlowska, M., et al. Biochem. J. 423(3):389-400(2009)Zhou, L., et al. J. Biol. Chem. 284(33):22426-22435(2009)Rashid, S., et al. J. Biol. Chem. 284(27):18115-18128(2009)Chandrasekar, B., et al. J. Biol. Chem. 283(36):24889-24898(2008)Fang, Q.C., et al. Zhonghua Yi Xue Za Zhi 88(6):369-373(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)

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$ 80.00
Cat# BP9874b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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