|Other Names||DCC-interacting protein 13-alpha, Dip13-alpha, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1, APPL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.|
|Cellular Location||Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF|
|Tissue Location||High levels in heart, ovary, pancreas and skeletal muscle.|
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APPL1 encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
Banach-Orlowska, M., et al. Biochem. J. 423(3):389-400(2009)Zhou, L., et al. J. Biol. Chem. 284(33):22426-22435(2009)Rashid, S., et al. J. Biol. Chem. 284(27):18115-18128(2009)Chandrasekar, B., et al. J. Biol. Chem. 283(36):24889-24898(2008)Fang, Q.C., et al. Zhonghua Yi Xue Za Zhi 88(6):369-373(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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