|Other Names||Fibroblast growth factor 3, FGF-3, Heparin-binding growth factor 3, HBGF-3, Proto-oncogene Int-2, FGF3, INT2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.|
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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.
Ramsebner, R., et al. Laryngoscope 120(2):359-364(2010)Charles, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106(52):22364-22368(2009)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Kang, W., et al. J. Neurosci. 29(46):14571-14580(2009)Alsmadi, O., et al. Eur. J. Hum. Genet. 17(1):14-21(2009)
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