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FOXK1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P85037
Peptide ID 36104
Additional Information
Gene ID 221937
Other Names Forkhead box protein K1, Myocyte nuclear factor, MNF, FOXK1 {ECO:0000303|PubMed:15202027, ECO:0000303|PubMed:15289879}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXK1 {ECO:0000303|PubMed:15202027, ECO:0000303|PubMed:15289879}
Function Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Important regulatory factor of the myogenic progenitor cell population. Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells. Represses myogenic differentiation by inhibiting MEFC acitivity. Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli. Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136).
Cellular Location Nucleus {ECO:0000255, ECO:0000269|PubMed:23186163}
Tissue Location Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.
Research Areas
Citations (0)

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Background

FOXK1 is a transcriptional activator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. It plays a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.

References

Olsen, J.V., et al. Cell 127(3):635-648(2006)Tsai, K.L., et al. J. Biol. Chem. 281(25):17400-17409(2006)Huang, J.T., et al. Int. J. Oncol. 25(3):751-757(2004)Katoh, M., et al. Int. J. Mol. Med. 14(1):127-132(2004)

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$ 80.00
Cat# BP9880b
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