|Other Names||Cell division control protein 45 homolog, PORC-PI-1, CDC45, CDC45L, CDC45L2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for initiation of chromosomal DNA replication.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Widely expressed, highest levels are found in adult testis and thymus and in fetal liver|
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The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.
Chowdhury, A., et al. Mol. Cell. Biol. 30(6):1495-1507(2010)Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15628-15632(2009)Ballabeni, A., et al. J. Biol. Chem. 284(5):3028-3036(2009)Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)Hoskins, J.M., et al. Clin. Cancer Res. 14(6):1788-1796(2008)
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