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CDC45L Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75419 |
|---|
| Gene ID | 8318 |
|---|---|
| Other Names | Cell division control protein 45 homolog, PORC-PI-1, CDC45, CDC45L, CDC45L2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDC45 (HGNC:1739) |
|---|---|
| Synonyms | CDC45L, CDC45L2 |
| Function | Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. |
| Cellular Location | Nucleus. Chromosome. Note=Associates with chromatin |
| Tissue Location | Widely expressed, highest levels are found in adult testis and thymus and in fetal liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.
References
Chowdhury, A., et al. Mol. Cell. Biol. 30(6):1495-1507(2010)Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15628-15632(2009)Ballabeni, A., et al. J. Biol. Chem. 284(5):3028-3036(2009)Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)Hoskins, J.M., et al. Clin. Cancer Res. 14(6):1788-1796(2008)
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