|Other Names||mRNA-decapping enzyme 1B, 3---, DCP1B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay.
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)Cougot, N., et al. J. Cell Biol. 165(1):31-40(2004)
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