|Other Names||RPE-retinal G protein-coupled receptor, RGR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Preferentially expressed at high levels in the retinal pigment epithelium (RPE) and Mueller cells of the neural retina|
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This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively).
Kochounian, H., et al. Exp. Eye Res. 88(6):1129-1136(2009)Radu, R.A., et al. J. Biol. Chem. 283(28):19730-19738(2008)Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)Lin, M.Y., et al. Mol. Vis. 13, 1203-1214 (2007)
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