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PHAR4 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8IZ21
Peptide ID 91113126
Additional Information
Gene ID 65979
Other Names Phosphatase and actin regulator 4, PHACTR4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Cellular Location Cytoplasm. Cell projection, lamellipodium
Research Areas
Citations (0)

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This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene.


Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Allen, P.B., et al. Proc. Natl. Acad. Sci. U.S.A. 101(18):7187-7192(2004)Sagara, J., et al. J. Biol. Chem. 278(46):45611-45619(2003)

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$ 80.00
Cat# BP9904b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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