|Other Names||THO complex subunit 7 homolog, Functional spliceosome-associated protein 24, fSAP24, Ngg1-interacting factor 3-like protein 1-binding protein 1, NIF3L1-binding protein 1, hTREX30, THOC7, NIF3L1BP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus speckle Note=Interaction with THOC5 is required for nuclear localization|
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Provided below are standard protocols that you may find useful for product applications.
El Bounkari, O., et al. FEBS Lett. 583(1):13-18(2009)Boyne, J.R., et al. PLoS Pathog. 4 (10), E1000194 (2008) Cheng, H., et al. Cell 127(7):1389-1400(2006)Masuda, S., et al. Genes Dev. 19(13):1512-1517(2005)
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