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NMRL1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9HBL8
Peptide ID 91113152
Additional Information
Gene ID 57407
Other Names NmrA-like family domain-containing protein 1, NMRAL1, HSCARG
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HSCARG
Function Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
Cellular Location Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios
Research Areas
Citations (0)

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Lian, M., et al. J. Biol. Chem. 284(27):17998-18006(2009)Dai, X., et al. J. Mol. Biol. 387(5):1277-1285(2009)Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) Zhao, Y., et al. J. Biol. Chem. 283(16):11004-11013(2008)

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$ 80.00
Cat# BP9906a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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