|Other Names||Lysophospholipid acyltransferase LPCAT4, 1-acylglycerol-3-phosphate O-acyltransferase 7, 1-AGP acyltransferase 7, 1-AGPAT 7, 1-acylglycerophosphocholine O-acyltransferase, 1-acylglycerophosphoserine O-acyltransferase, 231n6, 1-alkenylglycerophosphoethanolamine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acyltransferase-like 3, Lysophosphatidylcholine acyltransferase 4, Lysophosphatidylethanolamine acyltransferase 2, 231n7, Plasmalogen synthase, LPCAT4, AGPAT7, AYTL3, LPEAT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||AGPAT7, AYTL3, LPEAT2|
|Function||Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Widely expressed with predominant level in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 220.127.116.11) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction.
Cao, J., et al. J. Biol. Chem. 283(27):19049-19057(2008)Ye, G.M., et al. DNA Seq. 16(5):386-390(2005)
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