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UNG Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P13051 |
|---|---|
| Other Accession | NP_003353.1 |
| Gene ID | 7374 |
|---|---|
| Other Names | Uracil-DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_03166}, UDG {ECO:0000255|HAMAP-Rule:MF_03166}, 32227 {ECO:0000255|HAMAP-Rule:MF_03166}, UNG {ECO:0000255|HAMAP-Rule:MF_03166} |
| Target/Specificity | The synthetic peptide sequence is selected from aa 5-20 of HUMAN UNG |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | UNG {ECO:0000255|HAMAP-Rule:MF_03166} |
|---|---|
| Function | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. |
| Cellular Location | [Isoform 1]: Mitochondrion. |
| Tissue Location | Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2.
References
Ameratunga, R., et al. N. Z. Med. J. 122(1304):46-53(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Otterlei, M., et al. Nucleic Acids Res. 26(20):4611-4617(1998)
Haug, T., et al. Nucleic Acids Res. 26(6):1449-1457(1998)
Nilsen, H., et al. Nucleic Acids Res. 25(4):750-755(1997)
Mol, C.D., et al. Cell 82(5):701-708(1995)
Mol, C.D., et al. Cell 80(6):869-878(1995)
Haug, T., et al. FEBS Lett. 353(2):180-184(1994)
Slupphaug, G., et al. Nucleic Acids Res. 21(11):2579-2584(1993)
Slupphaug, G., et al. Nucleic Acids Res. 19(19):5131-5137(1991)
Olsen, L.C., et al. EMBO J. 8(10):3121-3125(1989)
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