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CFP Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P27918
Additional Information
Gene ID 5199
Other Names Properdin, Complement factor P, CFP, PFC
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFP
Synonyms PFC
Function A positive regulator of the alternate pathway (AP) of complement (PubMed:20382442, PubMed:28264884). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:20382442, PubMed:28264884). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604).
Cellular Location Secreted
Research Areas
Citations (0)
citation

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Background

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections.

References

Seitsonen, S., et al. Mol. Immunol. 47(6):1334-1336(2010)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Wolf-Schnurrbusch, U.E., et al. Retina (Philadelphia, Pa.) 29(7):966-973(2009)Keslar, K., et al. Transplantation 86(9):1319-1321(2008)Hartmann, S., et al. J. Biol. Chem. 275(37):28569-28574(2000)

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$ 277.78
Cat# BP9941c
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