|Other Names||ERC protein 2, ERC2, KIAA0378|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.|
|Cellular Location||Cytoplasm. Cell junction, synapse. Cell junction, synapse, synaptosome Cytoplasm, cytoskeleton. Note=In neurons, localized to synapses, and colocalizes with PCLO Localized to the active zone of presynaptic density (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ERCs (ERC1 and ERC2) also referred to as ELKS and CAST are related proteins which share an identical C-terminal sequence. They interact with the conserved RIM PDZ domain via an unusual PDZ binding motif. ERC2/CAST 1 is only expressed as a single RIM binding variant. All ERCs have been shown to interact with Rab6, a protein involved in membrane trafficking at the Golgi complex. The function of these proteins has not been determined yet. They may link Rab6 mediated non-neuronal membrane traffic at the Golgi complex to neuronal membrane traffic at the active zone executed via RIMs.
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)Kiel, D.P., et al. BMC Med. Genet. 8 SUPPL 1, S14 (2007) tom Dieck, S., et al. J. Cell Biol. 168(5):825-836(2005)
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