|Other Names||Adseverin, Scinderin, SCIN, KIAA1905|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton.|
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SCIN (Scinderin) is a Ca(2+) dependent actin filament severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro SCIN also has barbed end capping and nucleating activities in the presence of Ca(2+).
Chumnarnsilpa, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13719-13724(2009)Ehre, C., et al. Am. J. Physiol., Cell Physiol. 288 (1), C46-C56 (2005) Lejen, T., et al. Ann. N. Y. Acad. Sci. 971, 248-250 (2002)
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