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SCIN Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y6U3
Peptide ID 91102118
Additional Information
Gene ID 85477
Other Names Adseverin, Scinderin, SCIN, KIAA1905
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCIN
Synonyms KIAA1905
Function Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
Cellular Location Cytoplasm, cytoskeleton. Cell projection, podosome {ECO:0000250|UniProtKB:Q60604}
Tissue Location Expressed in megakaryocytes.
Research Areas
Citations (0)

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Background

SCIN (Scinderin) is a Ca(2+) dependent actin filament severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro SCIN also has barbed end capping and nucleating activities in the presence of Ca(2+).

References

Chumnarnsilpa, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13719-13724(2009)Ehre, C., et al. Am. J. Physiol., Cell Physiol. 288 (1), C46-C56 (2005) Lejen, T., et al. Ann. N. Y. Acad. Sci. 971, 248-250 (2002)

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$ 80.00
Cat# BP9945a
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