|Other Names||UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, GlcNAc-1-P transferase, G1PT, GPT, N-acetylglucosamine-1-phosphate transferase, DPAGT1, DPAGT2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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DPAGT1 encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme.
Nita-Lazar, M., et al. Cancer Res. 69(14):5673-5680(2009)Bretthauer, R.K. Curr Drug Targets 10(6):477-482(2009)Wu, X., et al. Hum. Mutat. 22(2):144-150(2003)
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