|Other Names||Mitochondrial inner membrane protease subunit 2, 3421-, IMP2-like protein, IMMP2L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein|
|Tissue Location||Expressed in all tissues tested except adult liver and lung.|
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Provided below are standard protocols that you may find useful for product applications.
IMP2L complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 (IMMP1L; MIM 612323) and IMP2 are the catalytic subunits of the IMP complex.
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Trynka, G., et al. Gut 58(8):1078-1083(2009)de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
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