|Other Names||Phostensin, Protein phosphatase 1 F-actin cytoskeleton-targeting subunit, Protein phosphatase 1 regulatory subunit 18, PPP1R18, HKMT1098, KIAA1949|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton.|
|Cellular Location||Isoform 1: Cytoplasm, cytoskeleton|
|Tissue Location||Isoform 4 is predominantly expressed in leukocytes and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
PHTNS interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin cytoskeleton。
Lai, N.S., et al. Biochem. Biophys. Res. Commun. 387(4):676-681(2009)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) Kao, S.C., et al. Biochem. Biophys. Res. Commun. 356(3):594-598(2007)
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