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SMAD3-S208 Antibody Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP9995a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
SMAD3-S208 Antibody Blocking Peptide - Product info | |
| Primary Accession | P84022 |
| Calculated MW | 48081 Da |
SMAD3-S208 Antibody Blocking Peptide - Additional info | |
| Gene ID 4088 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
SMAD3-S208 Antibody Blocking Peptide - Protein Information | |
| Name SMAD3 | |
| Synonyms MADH3 | |
| Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | |
| Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta | |
SMAD3-S208 Antibody Blocking Peptide - Related products
AP11730a: SMAD3 Antibody (S213)
AP3249a: Phospho-SMAD3-S208 Antibody
AP3250a: Phospho-SMAD3-S213 Antibody
AP6267a: SMAD3 Antibody (Center D201)
AP6267b: SMAD3 Antibody (Center N206)
RI14954: SMAD3 predesign siRNA
BP3248a: Phospho-SMAD3-S204 Antibody Blocking Peptide
BP3249a: Phospho-SMAD3-S208 Antibody Blocking Peptide
BP3250a: Phospho-SMAD3-S213 Antibody Blocking Peptide
BP6267a: SMAD3 Antibody (Center D201) Blocking Peptide
BP6267b: SMAD3 Antibody (Center N206) Blocking Peptide
BP9995a: SMAD3-S208 Antibody Blocking Peptide
SMAD3-S208 Antibody Blocking Peptide - Research Areas
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BACKGROUND
SMAD3 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
REFERENCES
Zhang, M., et al. J. Biol. Chem. 285(12):8703-8710(2010)Daly, A.C., et al. J. Biol. Chem. 285(9):6489-6497(2010)Heikkinen, P.T., et al. J. Biol. Chem. 285(6):3740-3749(2010)Tseng, Z.H., et al. Heart Rhythm 6(12):1745-1750(2009)
