|Other Names||CMP-N-acetylneuraminate-beta-1, 4-galactoside alpha-2, 3-sialyltransferase, Beta-galactoside alpha-2, 3-sialyltransferase 3, Alpha 2, 3-ST 3, Gal beta-1, 3(4) GlcNAc alpha-2, 3 sialyltransferase, N-acetyllactosaminide alpha-2, 3-sialyltransferase, ST3Gal III, ST3GalIII, ST3N, Sialyltransferase 6, ST3GAL3, SIAT6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3- GalNAc (By similarity).|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid|
|Tissue Location||Highly expressed in adult skeletal muscle and in all fetal tissues examined and to a much lesser extent in placenta, lung and liver|
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Provided below are standard protocols that you may find useful for product applications.
ST3GAL3 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29.
Carvalho, A.S., et al. Int. J. Biochem. Cell Biol. 42(1):80-89(2010)Grahn, A., et al. Glycoconj. J. 20 (7-8), 493-500 (2004) Taniguchi, A., et al. Biochim. Biophys. Acta 1626 (1-3), 92-96 (2003) Gretschel, S., et al. Oncology 65(2):139-145(2003)
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