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MAPK14 Over-expression LysateGene specific transient over-expression cell lysates
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| LY10174a | 100ug 400 ul | 3-4 weeks | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
MAPK14 Over-expression Lysate - Product info | |
| Application | WB
|
| Other Accession | NM_001315.2 |
MAPK14 Over-expression Lysate - Additional info | |
| Gene Symbol | MAPK14 |
| Other Names CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | |
| Format over-expression cell lysate in RIPA buffer | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MAPK14 Over-expression Lysate - Related products
AP12488c: MAPK14 Antibody (Center T180/Y182)
AP3422a: Phospho-MAPK14-pT179 Antibody
AP3438a: Phospho-MAPK14-pY323 Antibody
AP3604a: Phospho-MAPK14-pY182 Antibody
AP3642a: Phospho-MAPK14-pT180 Antibody
AP3643a: Bi-phospho-MAPK14-pT180/Y182 Antibody
AP7226c: MAPK14 Antibody (Center)
AP7226d: MAPK14 Antibody (Y323)
AP7226e: MAPK14 Antibody (T179)
AP7226f: MAPK14 Antibody (T180/Y182)
AP7508a: MAPK14 Antibody (N-term)
AP7546b: MAPK14 Antibody (C-term)
RI13188: MAPK14 predesign siRNA
MAPK14 Over-expression Lysate - Application data
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Western blot analysis of his-tag MAPK14 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAPK14 gene (Lane 2, Cat. #LY10174a).
MAPK14 Over-expression Lysate - Research Areas
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BACKGROUND
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
REFERENCES
[Construction of eukaryotic plasmid expression Hsf4b and phosphorylation of Hsf4b by MAP kinase P38] Ma ZY, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2010 Apr. PMID 20564821. Signaling pathways involved in postconditioning-induced cardioprotection of human myocardium, in vitro. Lemoine S, et al. Exp Biol Med (Maywood), 2010 Jun. PMID 20511681. Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. Shan L, et al. J Immunol, 2010 Jun 15. PMID 20483734. Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa. B?rub? J, et al. J Biol Chem, 2010 Jul 16. PMID 20460375. Carbonic anhydrase XII promotes invasion and migration ability of MDA-MB-231 breast cancer cells through the p38 MAPK signaling pathway. Hsieh MJ, et al. Eur J Cell Biol, 2010 Aug. PMID 20434230.
