Recombinant Human BAFF Receptor
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Description | BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFFR/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFFR is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFFR protein. |
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BiologicalActivity | Determined by its ability to block BAFF induced M splenocyte survival. The expected ED50 for this effect is 2.0-4.0 μg/ml in the presence of 1.0μg/ml of human soluble BAFF. |
Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
Endotoxin | Endotoxin level is <0.1 ng/ µg of protein (<1EU/ µg). |
Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
Storage | -20°C |
Precautions | Recombinant Human BAFF Receptor is for research use only and not for use in diagnostic or therapeutic procedures. |
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