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Recombinant Human IL -22
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Description | IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains. |
|---|---|
| BiologicalActivity | Assay #1: Determined by its ability to activate STAT following receptor ligand interaction. Assay #2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED50 for this effect is 0.7- 1.0 ng/ml. |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Endotoxin | Endotoxin level is <0.1 ng/ µg of protein (<1EU/ µg). |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Storage | -20°C |
| Precautions | Recombinant Human IL -22 is for research use only and not for use in diagnostic or therapeutic procedures. |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
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$ 216.00
$ 96.00
Cat# PBG10220-U010
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