Recombinant Rat Leptin
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Description | Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues. |
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BiologicalActivity | Determined by an in vivo assay using the ob/ob M obesity model and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls. |
Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
Endotoxin | Endotoxin level is <0.1 ng/ µg of protein (<1EU/ µg). |
Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
Storage | -20°C |
Precautions | Recombinant Rat Leptin is for research use only and not for use in diagnostic or therapeutic procedures. |
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