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Recombinant Human TACI (TNFRSF13B)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Description | TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 159 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein. |
|---|---|
| BiologicalActivity | Determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 µg/ml. |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Endotoxin | Endotoxin level is <0.1 ng/ µg of protein (<1EU/ µg). |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Storage | -20°C |
| Precautions | Recombinant Human TACI (TNFRSF13B) is for research use only and not for use in diagnostic or therapeutic procedures. |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
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$ 216.00
$ 96.00
Cat# PBG10431-U020
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