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Recombinant Human VCAM-1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Description | VCAM is a 110 kDa cell surface integral membrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. The primary function of VCAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 may play a vital role in the development several diseases, including atherosclerosis and rheumatoid arthritis. The human VCAM-1 gene codes for a 715 amino acid transmembrane glycoprotein containing a 19 amino acid cytoplasmic domain, a 22 amino acid transmembrane domain, and a 674 amino acid extracellular domain. Recombinant human VCAM-1 is a 74.0kDa glycoprotein comprising the extracellular domain (674 amino acid residues) of VCAM-1. Monomeric glycosylated VCAM-1 migrates at an apparent molecular weight of approximately 90.0kDa by SDS-PAGE analysis under reducing conditions. |
|---|---|
| BiologicalActivity | Determined by its ability to support the adhesion of human U937 cells. The expected ED50 for this effect is 0.8-1.0 μg/ml. |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Endotoxin | Endotoxin level is <0.1 ng/ µg of protein (<1EU/ µg). |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Storage | -20°C |
| Precautions | Recombinant Human VCAM-1 is for research use only and not for use in diagnostic or therapeutic procedures. |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
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$ 216.00
$ 96.00
Cat# PBG10469-U050
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