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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PARP Blocking Peptide    

PARP Blocking Peptide

Product Information
Primary Accession P09874
Other Accession NP_001609
Gene ID 142
Calculated MW 113084 Da
Additional Information
Gene ID 142
Application & Usage The peptide is used for blocking the antibody activity of active PARP. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C.
Other Names Poly [ADP-ribose] polymerase 1, PARP-1,, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, PARP1, ADPRT, PPOL
Target/Specificity PARP
Formulation 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPARP Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PARP1
Synonyms ADPRT, PPOL
Function Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Cellular Location Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage
Research Areas
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$ 95.00
Cat# PBV10000b
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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