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>   home   >   Products   >   Proteins   >   Procathepsin K, rat recombinant protein   

Procathepsin K, rat recombinant protein


Product info
Primary Accession P00786
Concentration 1
Calculated MW 35.4 kDa
Additional Info
Gene ID 25425
Gene Symbol CATK
Other Names CTSK, CTSO, CTSO3
Gene Source Rat
Source E.coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Results >400 mU/mg
Target/Specificity Procathepsin K
Format Liquid
Storage -80°C; 1 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).
Citations (0)

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Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.


Ishidoh K.,et al.FEBS Lett. 226:33-37(1987).
Ishidoh K.,et al.FEBS Lett. 253:103-107(1989).
Qian F.,et al.Int. J. Biochem. 22:1457-1464(1990).
Takio K.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:3666-3670(1983).

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$ 239.00
$ 895.00
$ 7,950.00
Cat# PBV10006r
(40 western blots)
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