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Caspase-11 Blocking Peptide

Product Information
Primary Accession P70343
Other Accession NM_007609
Gene ID 12363
Calculated MW 42742 Da
Additional Information
Gene ID 12363
Application & Usage The peptide is used for blocking the antibody activity of active Caspase-11. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C
Other Names Caspase-4, CASP-4,, Caspase-11, CASP-11, Protease ICH-3, Caspase-4 subunit p10, Caspase-4 subunit p20, Casp4, Casp11, Caspl, Ich3
Target/Specificity Caspase-11
Formulation 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCaspase-11 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casp4
Synonyms Casp11, Caspl, Ich3
Function Proinflammatory caspase (PubMed:8702803, PubMed:9038361, PubMed:25119034). Essential effector of NLRP3 inflammasome- dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria (PubMed:22002608). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:22002608, PubMed:26320999, PubMed:26375003). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of the infection (>3 days post infection), LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in the pyroptosis of the infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752). Involved in LPS- induced IL6 secretion; this activity may not require caspase enzymatic activity (By similarity). Involved in cell death induced by endoplasmic reticulum stress (By similarity). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:8702803, PubMed:9038361).
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49662}. Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49662}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49662}; Cytoplasmic side {ECO:0000250|UniProtKB:P49662}. Mitochondrion {ECO:0000250|UniProtKB:P49662}. Inflammasome. Secreted {ECO:0000250|UniProtKB:P49662}. Note=Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214. Released in the extracellular milieu by keratinocytes following UVB irradiation {ECO:0000250|UniProtKB:P49662}
Tissue Location Widely expressed, including in thymus, lung and spleen (at protein level). Very low levels, if any, in the brain.
Research Areas
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$ 95.00
Cat# PBV10007b
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