|Calculated MW||42742 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of active Caspase-11. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C|
|Other Names||Caspase-4, CASP-4, 126.96.36.199, Caspase-11, CASP-11, Protease ICH-3, Caspase-4 subunit p10, Caspase-4 subunit p20, Casp4, Casp11, Caspl, Ich3|
|Formulation||50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal|
|Reconstitution & Storage||-20 °C|
|Precautions||Caspase-11 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Casp11, Caspl, Ich3|
|Function||Involved in ER-stress induced apoptosis. Cleaves caspase-1 (By similarity). Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses.|
|Cellular Location||Endoplasmic reticulum membrane. Mitochondrion|
|Tissue Location||Mostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain|
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