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Caspase-1, human recombinant protein


Product info
Primary Accession P29466
Calculated MW large (20 kD) and small (10 kD) subunitsk
Additional Info
Gene ID 834
Gene Symbol CASP1
Other Names Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, IL-1 beta-converting enzyme, p45
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE;
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity Caspase-1
Application Notes Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Format Semi-Dry powder
Storage -70°C; Lyophilized powder
Citations (0)

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Caspase-1 (also know as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kD) and small (10 kD) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant active human caspase-1 was expressed in E. coli. The active caspase-1 preferentially cleaves caspase-1 substrates (e.g., YVAD-AFC or YVAD-pNA) and is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-YVAD-pNA or Ac-YVAD-AFC . The rh-Caspase has an N-term His-tag and corresponds to amino acids 120-404 of Caspase-1, gene accession# NP_150634.1.

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$ 325.00
$ 185.00
Cat# PBV10010r
(40 western blots)
Availability: 5-7days
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