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Caspase-5, human recombinant protein


Product info
Primary Accession P51878
Calculated MW 49736 Da
Additional Info
Gene ID 838
Gene Symbol CASP5
Other Names Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity Caspase-5
Application Notes Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Format Lyophilized powder
Storage -70°C; Lyophilized powder
Citations (0)

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Caspase-5 (also know as ICErelIII, TY) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-5 exists in cells as an inactive proenzyme which is matured by proteolysis to yield large and small subunits. The active caspase-5 is a heterotetramer consisting of two large and two small subunits. To date the mechanism of caspase-5 activation and roles of caspase-5 in apoptosis are poorly understood. The recombinant active human caspase-5 was expressed in E. coli. The active caspase-5 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-WEHD-pNA or Ac-WEHD-AFC


Eckhart L.,et al.Biochem. Biophys. Res. Commun. 348:682-688(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Munday N.A.,et al.J. Biol. Chem. 270:15870-15876(1995).
Faucheu C.,et al.Eur. J. Biochem. 236:207-213(1996).

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$ 305.00
$ 175.00
Cat# PBV10014r
(40 western blots)
Availability: 5-7days
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