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Caspase-8, mouse recombinant protein

Caspase 8

Product info
Primary Accession Q3U607
Additional Info
Gene ID 12370
Gene Symbol CASP8
Other Names Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog
Gene Source Mouse
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity Caspase-8
Application Notes Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Format Lyophilized powder
Storage -70°C; Lyophilized powder
Citations (0)

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Caspase-8 (also know as FLICE, MASH, Mch5) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-8 also exists in cells as an inactive proenzyme. During apoptosis procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of caspase-8 consists of large and small subunits which associate to form the active enzyme. Active caspase-8 has been shown to activate caspase-3 leading to degradation of a variety of cellular target proteins during apoptosis. The recombinant active mouse caspase-8 was expressed in E. coli. The active caspase-8 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-IETD-pNA or Ac-IETD-AFC

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$ 285.00
$ 145.00
Cat# PBV10030r
(40 western blots)
Availability: 5-7days
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