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Sonic Hedgehog (SHH), human recombinant protein

SHH; HHG1; HLP3; HPE3; SMMCI, Sonic hedgehog

Product info
Primary Accession Q15465
Calculated MW 19.697kDa
Additional Info
Gene ID 6469
Gene Symbol SHH
Other Names SHH; HHG1; HLP3; HPE3; SMMCI, Sonic hedgehog
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥97%
Assay2&Purity2 HPLC; ≥97%
Recombinant Yes
Results 750ng/ml.
Target/Specificity Sonic Hedgehog (SHH)
Application Notes When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile H₂O to a concentration of 0.1-0.5 mg/ml, which can be further diluted into other aqueous solutions.
Format Lyophilized protein
Storage -20°C; Lyophilized from a 10 mM sodium phosphate buffer, pH 7.5.
Citations (0)

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Recombinant Human Sonic Hedgehog (SHH) is a highly conserved protein that plays an important role in embryonic development. It is expressed in neural tissue, the gut, and areas of limb development and promotes differentiation and growth in a tissue-specific manner. SHH is synthesized as a 45-kDa precursor protein, which is then cleaved to generate the active 19-kDa N-terminus. SHH interacts with the Patched and Smoothened transmembrane receptors, leading to the activation of GLI family transcription factors. Disruption of any part of this pathway during embryogenesis is associated with birth defects ranging from mild to severe. In adults, abnormal activation of the SHH pathway has been implicated in several forms of cancer. Three mammalian hedgehog genes (sonic, desert, Indian) share about 60% homology. The Cys at position 25 has been substituted with Ile. Human SHH is a non-glycosylated polypeptide consisting of 175 amino acids with a molecular weight of 19,697 Da.


Marigo V.,et al.Genomics 28:44-51(1995).
Tate G.,et al.J. Biochem. Mol. Biol. Biophys. 4:27-34(2000).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Pepinsky R.B.,et al.J. Biol. Chem. 273:14037-14045(1998).

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$ 185.00
$ 595.00
$ 2,950.00
Cat# PBV10043r
(40 western blots)
Availability: 5-7days
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