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SIRT7 Blocking Peptide

     
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Product Information
Primary Accession B2RZ55
Gene ID 303745
Calculated MW 45113 Da
Additional Information
Gene ID 303745
Application & Usage The peptide is used for blocking the antibody activity of SIRT7. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names NAD-dependent protein deacetylase sirtuin-7, 3.5.1.-, Regulatory protein SIR2 homolog 7, SIR2-like protein 7, Sirt7
Target/Specificity SIRT7
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsSIRT7 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sirt7
Function NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation (By similarity).
Cellular Location Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
Research Areas
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$ 95.00
Cat# PBV10045b
Size:
Quantity:
(40 western blots)
Availability: 5-7days
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