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CD40Ligand/TRAP, murine recombinant protein
CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T c
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P27548 |
|---|---|
| Calculated MW | 16.4 kDa |
| Gene ID | 21947 |
|---|---|
| Gene Symbol | CD40-L |
| Other Names | CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L. |
| Gene Source | Mouse |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | <0.1 µg/ml. |
| Target/Specificity | CD40Ligand/TRAP |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers or stored at 4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Sterile filtered and then lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 0.1 M Arginine. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CD40 Ligand (CD40L/TRAP) is a type II transmembrane glycoprotein belonging to the TNF superfamily of ligands. Natually, CD40L is a membrane-bound protein, but proteolytically cleaved 15-18 kDa soluble forms of CD40L are also fully active. CD40L plays an important role in the proliferation and differentiation of B-cells, and is critical for immunoglobulin (Ig) class switching. Recombinant murine CD40 Ligand is a soluble 18 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CDE40L.
References
Armitage R.,et al.Nature 357:80-82(1992).
Spriggs M.K.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Tsitsikov E.N.,et al.Mol. Immunol. 31:895-900(1994).
Farrah T.,et al.Nature 358:26-26(1992).
Peitsch M.C.,et al.Int. Immunol. 5:233-238(1993).
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