CD40Ligand/TRAP, murine recombinant protein
CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T c
|Calculated MW||16.4 kDa|
|Other Names||CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L.|
|Application Notes||Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers or stored at 4°C for 1 week or –20°C for future use.|
|Storage||-20°C; Sterile filtered and then lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 0.1 M Arginine.|
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Provided below are standard protocols that you may find useful for product applications.
CD40 Ligand (CD40L/TRAP) is a type II transmembrane glycoprotein belonging to the TNF superfamily of ligands. Natually, CD40L is a membrane-bound protein, but proteolytically cleaved 15-18 kDa soluble forms of CD40L are also fully active. CD40L plays an important role in the proliferation and differentiation of B-cells, and is critical for immunoglobulin (Ig) class switching. Recombinant murine CD40 Ligand is a soluble 18 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CDE40L.
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Spriggs M.K.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
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Farrah T.,et al.Nature 358:26-26(1992).
Peitsch M.C.,et al.Int. Immunol. 5:233-238(1993).
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