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CNTF, rat recombinant protein

HCNTF, CNTF, Ciliary Neurotrophic Factor.

Product info
Primary Accession P26441
Calculated MW 22.834 kDa
Additional Info
Gene ID 1270
Gene Symbol CNTF
Other Names HCNTF, CNTF, Ciliary Neurotrophic Factor.
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥99%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity CNTF
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile ddH₂O or 0.4 % NaHCO₃ adjusted to pH 8-9 to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffer, preferably in the presence of carrier protein.
Format Lyophilized protein
Storage -20°C; Lyophilized from 0.025 % NaHCO₃
Citations (0)

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CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. CNTF is a survival factor for various neuronal cell types and seems to prevent the degeneration of motor axons after axotomy. CNTF Recombinant Rat produced in E.Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 22834 Dalton. The CNTF is purified by proprietary chromatographic techniques.


Masiakowski P.,et al.J. Neurochem. 57:1003-1012(1991).
Negro A.,et al.Eur. J. Biochem. 201:289-294(1991).
Lam A.,et al.Gene 102:271-276(1991).
McDonald J.R.,et al.Biochim. Biophys. Acta 1090:70-80(1991).
Takahashi R.,et al.Nat. Genet. 7:79-84(1994).

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$ 3,000.00
$ 565.00
$ 195.00
Cat# PBV10049r
(40 western blots)
Availability: 5-7days
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