|Concentration||0.2 to 0.4|
|Calculated MW||75.0 kDa|
|Other Names||S- protein, Serum-spreading factor, V75|
|Application Notes||Reconstitute in H₂O or aqueous buffers to a concentration not less than 0.1 mg/ml. Aliquot and store at –20°C. Avoid freeze-thaw cycles.|
|Storage||-20°C; Lyophilized from 10 mM sodium phosphate, pH 7.7|
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Provided below are standard protocols that you may find useful for product applications.
Vitronectin and plasminogen activator inhibitor type 1 are proteins that interact in the circulatory system and pericellular region to regulate fibrinolysis, cell adhesion, and migration. Plasminogen activator inhibitor type 1, a serine proteinase, through its binding to the plasma protein vitronectin, influences processes that are key regulators of hemostatic process, for example, thrombosis and wound healing. In addition, the vitronectin and plasminogen activator inhibitor type 1 complex regulates binding of blood platelets and cells to extracellular substrata in events like tumor metastasis. The plasma concentration of vitronectin is 200 to 400 µg/ml.
Suzuki S.,et al.EMBO J. 4:2519-2524(1985).
Suzuki S.,et al.Submitted (JUN-1986) to the PIR data bank.
Jenne D.E.,et al.EMBO J. 4:3153-3157(1985).
Jenne D.E.,et al.Biochemistry 26:6735-6742(1987).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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