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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   DNMT3a Blocking peptide   

DNMT3a Blocking peptide

Product Information
Primary Accession Q9Y6K1
Gene ID 1788
Calculated MW 101858 Da
Additional Information
Gene ID 1788
Application & Usage The peptide is used for blocking the antibody activity of DNMT3a. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names DNA (cytosine-5)-methyltransferase 3A, Dnmt3a,, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A
Target/Specificity DNMT3a
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsDNMT3a Blocking peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Cellular Location Nucleus. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin
Tissue Location Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Research Areas
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$ 95.00
Cat# PBV10088b
(40 western blots)
Availability: 5-7days
Bulk Size
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