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Eosinophil Peroxidase, Human Eosinophils recombinant protein

EPO

     
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  • CITATIONS
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Product info
Primary Accession P11678
Calculated MW 70.5 kDa
Additional Info
Gene ID 8288
Gene Symbol EPX
Other Names EPO, EPER, EPP
Gene Source Human
Source Human eosinophils
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant No
Target/Specificity Eosinophil Peroxidase
Application Notes Reconstitute in deionized H₂O. Aliquot and store at –20°C. Avoid freeze-thaw cycles.
Format Lyophilized protein
Storage -20°C; Lyophilized from 20 mM NaH2PO4, pH 7.5, and 150 mM NaCI
Citations (0)

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Background

Native, human eosinophil peroxidase is a secreted hemoprotein that catalyzes oxidations of various substrates by hydrogen peroxide. Together with other leukocyte-derived enzymes, such as Myeloperoxidase, EPO plays an important role in the pathogenesis of asthma by mediating oxidative events that lead to the production of ROS (reactive oxygen species) and RNS (reactive nitrogen species).

References

Sakamaki K.,et al.J. Biol. Chem. 264:16828-16836(1989).
Ten R.M.,et al.J. Exp. Med. 169:1757-1769(1989).
Oxvig C.,et al.J. Biol. Chem. 274:16953-16958(1999).
Borelli V.,et al.Infect. Immun. 71:605-613(2003).
Ulrich M.,et al.J. Biol. Chem. 283:28629-28640(2008).

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$ 245.00
$ 725.00
Cat# PBV10094r
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