IFN-gamma, murine recombinant protein
Immune Interferon-γ, type II interferon, T cell interferon, MAF
|Calculated MW||15.6 kDa|
|Other Names||Immune Interferon-γ, type II interferon, T cell interferon, MAF|
|Application Notes||Reconstitute in ddH₂O to a concentration of 1 mg/ml. Further dilutions should be made into RPMI + 10% FCS and stored at 4°C for 1 week or –20°C for future use.|
|Storage||-20°C; Lyophilized from 10 mM Na2PO4, pH 7.0 + 25 mM NaCl|
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Provided below are standard protocols that you may find useful for product applications.
IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Recombinant murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.
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