IGF-I, human recombinant protein
Insulin-Like Growth Factor 1, Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF
|Calculated MW||7.6 kDa|
|Other Names||Insulin-Like Growth Factor 1, Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF|
|Application Notes||Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other buffered solutions or stored at 4°C for 1 week or –20°C for future use.|
|Format||Recombinant IGF-1 is available as a lyophilized powder|
|Storage||-20°C; IGF-1 protein is lyophilized with no additives|
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Provided below are standard protocols that you may find useful for product applications.
Human IGF-1 (insulin-like Growth Factor-1, IGF1, MGF, Somatomedin) is a hormone similar in molecular structure to insulin. It is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-1 binds to at least two cell surface receptors: the IGF-1 receptor (IGF1R), and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Mature human IGF I shares 94% and 96% aa sequence identity with mouse IGF1 and rat IGF1, respectively, and exhibits cross species activity. It shares 64% aa sequence identity with mature human IGFII. Human IGF-1 is a 7.6 kDa protein containing 70 amino acid residues. The recombinant human IGF-1 was produced using animal origin free technology.
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