|Calculated MW||27246 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of ERAB/HCD2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||3-hydroxyacyl-CoA dehydrogenase type-2, 22.214.171.124, 17-beta-hydroxysteroid dehydrogenase 10, 17-beta-HSD 10, 126.96.36.199, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 188.8.131.52, 3-hydroxyacyl-CoA dehydrogenase type II, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, Mitochondrial ribonuclease P protein 2, Mitochondrial RNase P protein 2, Type II HADH, Hsd17b10, Erab, Hadh2|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||ERAB/HCD2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (By similarity).|
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