IL-1 beta, rat recombinant protein
Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediato
|Calculated MW||17.3 kDa|
|Other Names||Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at +4°C for 1 week or –20°C for future use.|
|Storage||-20°C; Sterile filtered and then lyophilized from 10 mM Sodium Acetate, pH 6.5|
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Provided below are standard protocols that you may find useful for product applications.
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, B-cell maturation and proliferation, mitogenic FGF-like activity and stimulation of the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1β is a 17.4 kDa protein containing 153 amino acid residues.
Feeser W.,et al.Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases.
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