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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   DNMT3b Blocking peptide   

DNMT3b Blocking peptide

Product Information
Primary Accession Q9UBC3
Gene ID 1789
Calculated MW 95751 Da
Additional Information
Gene ID 1789
Application & Usage The peptide is used for blocking the antibody activity of DNMT3b. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names DNA (cytosine-5)-methyltransferase 3B, Dnmt3b,, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB, DNMT3B
Target/Specificity DNMT3b
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsDNMT3b Blocking peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
Cellular Location Nucleus
Tissue Location Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate
Research Areas
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$ 95.00
Cat# PBV10117b
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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