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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   MBD1 Blocking Peptide   

MBD1 Blocking Peptide

Product Information
Primary Accession Q9UIS9
Gene ID 4152
Calculated MW 66607 Da
Additional Information
Gene ID 4152
Application & Usage The peptide is used for blocking the antibody activity of MBD1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Methyl-CpG-binding domain protein 1, CXXC-type zinc finger protein 3, Methyl-CpG-binding protein MBD1, Protein containing methyl-CpG-binding domain 1, MBD1, CXXC3, PCM1
Target/Specificity MBD1
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsMBD1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBD1
Synonyms CXXC3, PCM1
Function Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Cellular Location Nucleus. Nucleus matrix. Nucleus speckle. Chromosome. Note=Colocalizes with the Ten-1 ICD form of TENM1 in foci associated with the nuclear matrix (By similarity). Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes.
Tissue Location Widely expressed.
Research Areas
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$ 95.00
Cat# PBV10120b
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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